Emergence of Extensive Drug Resistant ( XDR ) Mycobacterium 1 tuberculosis and Molecular Characterization of these clinical isolates 2 from Delhi Region , India 3 4

4 Alka Khanna 1,4 , V. Samuel Raj 2 , Bansidhar Tarai 5 , Ruchi Sood 2 , Pawan Kumar Pareek 2 , 5 Dilip J. Upadhyay 2 , Pawan Sharma 3 , Ashok Rattan 5,6 , Kulvinder Singh Saini 1 * and 6 Harpal Singh 4 * 7 8 Department of Biotechnology 1 , Department of Infectious Diseases 2 , New Drug Discovery 9 Research, Ranbaxy Research Laboratories, R & D III, Sector – 18, Gurgaon – 122 015, 10 India; International Centre for Genetic Engineering and Biotechnology 3 , Aruna Asaf Ali 11 Marg, New Delhi – 110 067; Centre for Biomedical Engineering 4 , Indian Institute of 12 Technology, Delhi, India; Clinical Reference Lab 5 , Super Religare Laboratories, Sector13 18, Gurgaon-122 015, India; Fortis Clinical Research Ltd. 6 , Sector-16-A, Faridabad-121 14 002, India. 15 16 17 18 *Address for Correspondence: 19 Dr. Kulvinder Singh Saini 20 Director-Biotechnology 21 New Drug Discovery Research 22 Ranbaxy Research Laboratories 23 R & D III, Sector-18 24 Gurgaon – 122 015, India 25 26 Phone: 91-124-2342001 Ext. 5045 27 Fax: 91-124-2343544 28 E-mail: [email protected] 29 30 *Address for Correspondence: 31 Dr. Harpal Singh 32 ProfessorCentre for Biomedical Engineering 33 Indian Institute of Technology 34 Block-III, Hauz Khas 35 New Delhi-110 016, India 36 37 Phone: 91-11-26591149 38 Fax: 91-11-26582037, 26582277 39 E-mail: [email protected] 40 Copyright © 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00661-10 AAC Accepts, published online ahead of print on 16 August 2010